The indazole 3 carboxylic acid Diaries
The indazole 3 carboxylic acid Diaries
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The indazole Main is a fascinating pharmacophore as a result of its applications in medicinal chemistry. In the past few years, this moiety continues to be utilized for the synthesis of kinase inhibitors.
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indazole substitution pattern, nonetheless, they call for harsh conditions or prolonged routes to The real key intermediates limiting their software. Selective N
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Even more, indazole group formed hydrophobic interactions with HDAC6, Whilst the cap groups occupied the Room outside the groove. The oxygen atom of the hydroxamic acid group formed a hydrogen bond with Tyr312 and the nitrogen atom shaped a hydrogen bond with His143.
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